tert-Butyl (5-fluoro-1,3-thiazol-2-yl)carbamate

tert-Butyl (5-fluoro-1,3-thiazol-2-yl)carbamate - Names and Identifiers

Name	tert-butyl (5-fluoro-1,3-thiazol-2-yl)carbamate
Synonyms	tert-butyl5-fluorothiazol-2-ylcarbamate tert-butyl 5-fluoro-1,3-thiazol-2-ylcarbamate tert-butyl (5-fluoro-1,3-thiazol-2-yl)carbamate tert-Butyl (5-fluoro-1,3-thiazol-2-yl)carbamate N-(5-fluoro-2-thiazolyl)-, 1,1-diMethylethyl ester (5-Fluoro-thiazol-2-yl)-carbaMic acid tert-butyl ester (5-Fluoro-2-thiazolyl)carbamic acid 1,1-dimethylethyl ester Carbamic acid, (5-fluoro-2-thiazolyl)-, 1,1-dimethylethyl ester carbamic acid, N-(5-fluoro-2-thiazolyl)-, 1,1-dimethylethyl ester Carbamic acid, (5-fluoro-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI) Carbamic acid, N-(5-fluoro-2-thiazolyl)-, 1,1-dimethylethyl ester
CAS	731018-54-5
InChI	InChI=1/C8H11FN2O2S/c1-8(2,3)13-7(12)11-6-10-4-5(9)14-6/h4H,1-3H3,(H,10,11,12)

tert-Butyl (5-fluoro-1,3-thiazol-2-yl)carbamate - Physico-chemical Properties

Molecular Formula	C8H11FN2O2S
Molar Mass	218.25
Density	1.319±0.06 g/cm3(Predicted)
pKa	4.47±0.70(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.549

tert-Butyl (5-fluoro-1,3-thiazol-2-yl)carbamate - Introduction

tert-butyl (5-fluoro-1,3-thiazol-2-yl)carbamate is an organic compound with the chemical formula C10H15FN2O2S. The following is an introduction to some of its properties, uses, methods and safety information:

Nature:
-Appearance: colorless or light yellow liquid;
-Melting point: about 25 ℃;
-Boiling point: about 250 ℃;
-Density: about 1.192g/cm³;
-Solubility: Soluble in some organic solvents, such as chloroform, ether, etc.

Use:
tert-butyl (5-fluoro-1,3-thiazol-2-yl)carbamate have certain applications in the chemical and pharmaceutical fields. It can be used as intermediates and raw materials, and participate in the synthesis of various compounds, such as drugs, pesticides and key parts in organic synthesis. Specific applications also include the study of anti-gastric ulcer drugs and the synthesis of pesticides.

Preparation Method:
The preparation method of tert-butyl (5-fluoro-1,3-thiazol-2-yl)carbamate is more complicated, and a possible synthetic route is as follows:
1.2-amino -5-fluorothiazole reacts with tert-butyl carbonate to generate tert-butyl (5-fluoro-1,3-thiazol-2-yl)carbamate.

Safety Information:
- tert-butyl (5-fluoro-1,3-thiazol-2-yl)carbamate is an organic compound, direct contact with skin and inhalation should be avoided;
-Wear appropriate personal protective equipment such as gloves, glasses, etc. during use or handling;
-Avoid contact with strong oxidants and strong acids;
-When storing, keep the container tightly closed and store it in a dry, low temperature, and well-ventilated place;
-In case of discomfort or abnormal reaction after contact or inhalation, seek medical attention immediately.

Last Update：2024-04-09 02:00:47